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Organic anion transporter 3

Witrynaporter 2 (OAT2) and rat organic anion transporter 3(OAT3)areresponsible for the renal transport of PFOA by comparing the renal clearance (CL R)of PFOA with mRNA levels of various organic anion transporters in the kidney under various hormonal states.9) To date, howev er, no information is avail-able on the molecular mechanism by which … Witryna10 gru 2014 · Organic anion transporter 3 inhibition increased bumetanide concentration in dialysate. To assess the extent of bumetanide transport into the brain at steady state, bumetanide was administered to all rats as an intravenous 10 mg/kg bolus followed by an infusion of 6 mg/kg/h.

Reduced Organic Anion Transporter Expression Is a Risk Factor …

Witryna1 lip 2016 · The initial step in renal secretion of organic anions (OAs) is mediated by transporters in the basolateral membrane (BLM). Contributors to this process are … Witryna10 sty 2003 · Mediates the Na +-independent transport of organic anions such as the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, taurocholate, estrone 3-sulfate, estradiol-17beta-glucuronide and prostaglandin E2 (PGE2) (PubMed:10873595, PubMed:19129463). Shows a pH-sensitive substrate specificity … in flight entertainment turkish airlines https://aeholycross.net

有机阴离子转运蛋白3(OAT3)多肽A片段

Witryna5 paź 2010 · Function. ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates … Witryna7 lis 2024 · 2. Transporters involved in the handling of uric acid in vivo. Uric acid possesses two ionizable groups with pKa values of 5.4 and 10.3; as such, this metabolite exists as a monovalent urate anion under physiological conditions with pH 7.4 [6,7].This ionized form is not diffusible across biological membranes; therefore, both excretion … WitrynaThe organic anion transporters 1 (OAT1) and 3 (OAT3) take up acidic xenobiotics from the pericapillary space in exchange for alpha-ketoglutarate and other dicarboxylic … inflight entertainment careers

OAT3/SLC22A8 Inhibitors DrugBank Online

Category:Organic Anion Transporter 1 - an overview ScienceDirect Topics

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Organic anion transporter 3

solute carrier organic anion transporter family, member 3A1

WitrynaSolute carrier family. The solute carrier ( SLC) group of membrane transport proteins include over 400 members organized into 66 families. [1] [2] Most members of the SLC group are located in the cell membrane. The SLC gene nomenclature system was originally proposed by the HUGO Gene Nomenclature Committee ( HGNC) and is the … WitrynaThe organic anion transporters 1 (OAT1) and 3 (OAT3) take up acidic xenobiotics from the pericapillary space in exchange for alpha-ketoglutarate and other dicarboxylic …

Organic anion transporter 3

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WitrynaNational Center for Biotechnology Information Witryna1 kwi 2006 · The human organic anion transporter, OAT3 (SLC22A8), plays a critical role in renal drug elimination, by mediating the entry of a wide variety of organic …

Witrynaヒトの有機アニオントランスポーター1(organic anion transporter 1 : OAT1)は、563アミノ酸残基からなる12回膜貫通型の膜タンパクで、主として腎臓に局在し、わずかに脳にも発現が認められています。 WitrynaRenal proximal and distal tubules are highly polarized epithelial cells that carry out the specialized directional transport of various solutes. This renal function, which is essential for homeostasis in the body, is achieved through the close pairing of apical and basolateral carriers expressed in the renal epithelial cells. The family of organic …

WitrynaThis was the first organic anion transporter to be identified in the human placenta, where it is expressed abundantly and plays an important role in the uptake of organic anions from the fetus [6]. The expression of OAT4 along with OAT3 was confirmed by RT-PCR in the adrenal cortex as well as the adrenocortical cell line NCI-H295R [7]. …

WitrynaOfficial Symbol : SLCO3A1 Official Name : solute carrier organic anion transporter family, member 3A1 EnsemblGene ID : Other Names : solute carrier family 21 (organic anion transporter), member 11, OATPRP3, FLJ40478, OATP3A1, solute carrier organic anion transporter family member 3A1, PGE1 transporter, SLC21A11, …

WitrynaOrganic anion transporter 3 (OAT3) plays a significant role in the uptake of methotrexate into the renal proximal tubule cells. Therefore, inhibitors of organic … inflight entertainment southwest airlinesWitrynaSolute carrier organic anion transporter family member 1B3: transporter: Novobiocin: Solute carrier organic anion transporter family member 2B1: transporter: Liotrix: Thyroid hormone receptor alpha: target: Liotrix: Thyroid hormone receptor beta: target: Liotrix: Cytochrome P450 2C8: enzyme: Liotrix: Solute carrier organic anion … inflight entertainment unitedWitryna14 lip 2024 · Human sodium phosphate co-transporter type 4 (NPT4/SLC17A3) is a multi-specific organic anion efflux transporter expressed in the kidneys and liver. NPT4 is located at the apical side of renal tubules, and functions as an apical voltage-driven urate efflux transporter, also known as NPT4-Na + /phosphate co-transporter … in flight entertainment on american airlineshttp://jhs.pharm.or.jp/data/53(1)/53_77.pdf in-flight entertainment wikipediaWitryna22 wrz 2024 · The organic anion transporters OAT1 (SLC22A6) and OAT3 (SLC22A8) have similar substrate specificity for drugs, but it is far from clear whether this holds … in flight entertainment system etihad airwaysWitrynaView/Edit Mouse. Solute carrier organic anion transporter family member 1B3 (SLCO1B3) also known as organic anion-transporting polypeptide 1B3 (OATP1B3) … in-flight entertainment virgin australiaWitrynaThe main adverse effect is organic cation transporter 2 (OCT2)-mediated nephrotoxicity, observed in 30% of patients. The contribution of other renal drug … inflight exchange