Witrynaporter 2 (OAT2) and rat organic anion transporter 3(OAT3)areresponsible for the renal transport of PFOA by comparing the renal clearance (CL R)of PFOA with mRNA levels of various organic anion transporters in the kidney under various hormonal states.9) To date, howev er, no information is avail-able on the molecular mechanism by which … Witryna10 gru 2014 · Organic anion transporter 3 inhibition increased bumetanide concentration in dialysate. To assess the extent of bumetanide transport into the brain at steady state, bumetanide was administered to all rats as an intravenous 10 mg/kg bolus followed by an infusion of 6 mg/kg/h.
Reduced Organic Anion Transporter Expression Is a Risk Factor …
Witryna1 lip 2016 · The initial step in renal secretion of organic anions (OAs) is mediated by transporters in the basolateral membrane (BLM). Contributors to this process are … Witryna10 sty 2003 · Mediates the Na +-independent transport of organic anions such as the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, taurocholate, estrone 3-sulfate, estradiol-17beta-glucuronide and prostaglandin E2 (PGE2) (PubMed:10873595, PubMed:19129463). Shows a pH-sensitive substrate specificity … in flight entertainment turkish airlines
有机阴离子转运蛋白3(OAT3)多肽A片段
Witryna5 paź 2010 · Function. ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates … Witryna7 lis 2024 · 2. Transporters involved in the handling of uric acid in vivo. Uric acid possesses two ionizable groups with pKa values of 5.4 and 10.3; as such, this metabolite exists as a monovalent urate anion under physiological conditions with pH 7.4 [6,7].This ionized form is not diffusible across biological membranes; therefore, both excretion … WitrynaThe organic anion transporters 1 (OAT1) and 3 (OAT3) take up acidic xenobiotics from the pericapillary space in exchange for alpha-ketoglutarate and other dicarboxylic … inflight entertainment careers