WebJun 1, 2024 · 4500 Background: Programmed death-1 (PD-1) inhibitor–based combination therapy shows clinical benefit in first-line accRCC. However, data are limited on clinical impact of first-line PD-1 inhibitor monotherapy. KEYNOTE-427 (NCT02853344) is a single-arm, open-label, 2-cohort, phase 2 study that evaluates efficacy and safety of the PD-1 … Web1 day ago · Thus, the incidence rate ratio (IRR) for the pandemic period to pre-pandemic period incidence rates was 0.5 (95% CI, 0.5-0.6; P <.001). The burden of ARI in the HIVE cohort during the COVID-19 pandemic fluctuated, with declines occurring concurrently with the widespread use of public health measures.
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WebDec 11, 2015 · Progression-Free Survival (PFS), as assessed by a blinded independent radiological review (IRR), is defined as the time from randomization to first documentation of objective tumor progression (progressive disease) or death due to any reasons whichever comes first. ... Subjects with metastatic RCC who have failed 2 or 3 prior systemic … WebAug 24, 2024 · Renal involvement is very common in GPA and MPA, especially at the onset of the disease . ... Overall, the rate of infusion reactions was low (5%) [40,75] Infusion related-reactions (IRR) are usually mild to moderate, though fatal evolutions have been reported [40,75]. The most common IRR are fever, rash, itching, ... iohannis photos