Cisplatin function
WebOct 5, 2014 · Exposure to oxidative stress can upset regular biological functions. Cisplatin also induces reactive oxygen species that trigger cell death besides DNA damage. … WebSep 15, 2024 · Cisplatin forms irreversible covalent links with DNA, causing cross linking of DNA chains as well as breaks in the DNA chain and missense mutations. The DNA injury …
Cisplatin function
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WebAcute kidney injury is a known side effect of cisplatin treatment, and kidney dysfunction results in the accumulation of uremic toxins in the serum. The present study aimed to investigate whether indoxyl sulfate (IS), a representative uremic toxin, affects the pathophysiology of EOC. ... These findings demonstrate that IS promotes malignancy in ... WebAug 6, 2014 · Cisplatin and other platinum derivatives are the most widely used chemotherapeutic agents to treat solid tumors including ovarian, head and neck, and testicular germ cell tumors. A known complication of …
WebPurpose: The objective of this study was to develop a pH-dependent calcium carbonate nano-delivery system for the combination therapy of CDDP with oleanolic acid (OA). Methods: A microemulsion method was employed to generate lipid coated cisplatin/oleanolic acid calcium carbonate nanoparticles (CDDP/OA-LCC NPs), and the …
WebFeb 16, 2024 · What is cisplatin? Cisplatin is used together with other cancer drugs to treat bladder cancer, testicular cancer, or ovarian cancer. Cisplatin may also be used for … WebCisplatin is a chemotherapy drug which is used to treat cancers including: sarcoma, small cell lung cancer, germ cell tumors, lymphoma, and ovarian cancer. While it is …
WebCisplatin is a type of chemotherapy. It destroys quickly dividing cells, such as cancer cells. Find out more about how chemotherapy works How do you have cisplatin? You have cisplatin as a drip into your bloodstream (intravenously). Into your bloodstream You might have treatment through a long plastic tube that goes into a large vein in your chest.
WebMar 15, 2024 · Cisplatin is a bedrock of cancer management and one of the most used chemotherapeutic agents in the treatment of germ cell, lung, bladder, ovarian, and head and neck cancers. Approximately 500,000 patients diagnosed annually with these cancer types in the United States could be candidates for treatment with cisplatin. orange is the new black big booWebCisplatin stimulates production of reactive oxygen species and oxidative stress by depleting and inactivating glutathione and other related antioxidants. • Cisplatin induces both … iphone shortcut download youtubeWebtoxicity have been reported. Cisplatin should be used with caution in patients with pre-existing hepatic dysfunction. Impaired Renal Function Cisplatin displays high tissue uptake in the kidneys and exhibits dose-related and cumulative nephrotoxicity. It is excreted mainly in the urine. The plasma elimination half-life of cisplatin iphone shortcut downloadsWebCisplatin has been a mainstay of cancer chemotherapy since the 1970s. Despite its broad anticancer potential, its clinical use has regularly been constrained by kidney toxicities. … orange is the new black ausgangWebOct 3, 2024 · Unfortunately, some chemotherapies can also cause strokes, such as methotrexate, cisplatin, imatinib and more. Some agents, such as bevacizumab and sunitinib, intentionally target blood vessels since tumors often create new vessels to send nutrients to the abnormal growth. Unfortunately, side effects can include hemorrhage or … iphone shortcut real battery healthWebCisplatin(cis-dichlorodiammineplatinum)–platinum coordination complex is an effective chemotherapy against a wide spectrum of tumors such as testicular, head and neck, … iphone shortcut to disable face idWebCisplatin has disturbed mitochondrial function and dynamics, dysregulate redox status and induced mitophagy and apoptosis, in the other hand semaglutide treatment has normalized dysregulated mitochondrial function and dynamics, … orange is the new black black cast