Cisplatin and kidney injury

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August undefined, 2024

WebJan 3, 2024 · All of these drugs can affect the glomerulus, tubules, interstitium, or renal microvasculature via different mechanisms, with clinical manifestations that range from an asymptomatic elevation of serum creatinine and electrolyte disorders to acute kidney injury requiring dialysis. WebRT @NatMetabolism: RESEARCH From Tomohito Doke et al. (@Penn): NMN & NR supplementation has protective effects on kidney injury by preventing cisplatin-induced …

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WebOct 15, 2024 · Cisplatin administration for acute kidney injury (AKI) leads to serious side effects and there is a higher risk of death [2]. In clinical practice, the main causes of AKI are infections, nephrotoxic drugs, diabetes, hypertension, sepsis and cardiovascular disease. WebNov 1, 2024 · Cisplatin is a widely used chemotherapeutic drug with notorious toxicity in the kidneys, which involves mitochondrial dysfunction and damage in renal tubular cells. Mitophagy is a form of... how to say nein in german

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WebMar 23, 2024 · For nearly five decades, cisplatin has played an important role as a standard chemotherapeutic agent and been prescribed to 10-20% of all cancer patients. Although nephrotoxicity associated with platinum-based agents is well recognized, treatment of cisplatin-induced acute kidney injury is mainly su … WebNov 3, 2024 · The kidney injury caused by cisplatin can present in a variety of ways. As it was clearly proved in some researches, the most serious and common damage induced by cisplatin is acute kidney injury (AKI) which occurs in 20–30% of patients, following a single injection of cisplatin [ 4 ]. WebMay 8, 2024 · Additionally, patients who did not receive mannitol with cisplatin were 2.6 times more likely to develop acute kidney injury. Implications for Practice. Overall, Duffy et al. said that the evidence regarding interventions to prevent nephrotoxicity is still limited and unable to support best practices for patients. They called for additional ... north lanarkshire nhs board

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Acute kidney injury during cisplatin therapy and ... - Springer

WebDec 21, 2024 · The clinical use of cisplatin has been hampered by its dose-dependent side effects, e.g., nephrotoxicity, and the precise mechanism(s) related to such a cisplatin … WebJan 29, 2024 · Fig. 1: Cisplatin induced Renal injury were alleviated by Ferroptosis inhibitor Ferrostatin-1 (Fer-1). A, B Serum BUN and Cr levels of each group at 48 h and 72 h after cisplatin injection. C... north lanarkshire nursery holidaysWebThe most direct evidence for NLRP3 involvement in CIN comes from NLRP3-specific inhibitor experiments that showed protection against CIN. Cisplatin-induced kidney injury was mitigated by chemical inhibition of NLRP3 with MCC950, demonstrating the role of the NLRP3 inflammasome in exacerbating CIN directly . north lanarkshire planning phone number

"WebFeb 18, 2024 · The ability of cisplatin (cis-diamminedichloroplatinum II) toxicity to induce acute kidney injury (AKI) has attracted attention and concern for a long time, but the molecular mechanism of... " - Cisplatin and kidney injury

Cisplatin and kidney injury

Full article: Cisplatin-induced oxidative stress stimulates renal …

WebApr 14, 2024 · For instance, intraperitoneal nicotinamide improves kidney function in mice with acute kidney injury induced by ischemia/reperfusion or treatment with cisplatin [29 ... . Activation of endoplasmic reticulum stress response by enhanced polyamine catabolism is important in the mediation of cisplatin-induced acute kidney injury. PLoS ONE 2024, ... WebA known complication of cisplatin administration is acute kidney injury (AKI). The nephrotoxic effect of cisplatin is cumulative and dose-dependent and often necessitates …

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WebDec 2, 2024 · It is well recognized that cisplatin may induce acute kidney injury (AKI) during chemotherapy. However, recent work further indicates that cisplatin treatment may have long-term effects in kidneys resulting in the development or progression of chronic kidney disease (CKD) in treated patients ( 16 ). WebOct 22, 2024 · Dose-dependent progression to CKD by repeated cisplatin administration. In order to evaluate the kidney injury after repeated injection of different doses of cisplatin in vivo, male wild type mice ...

WebApr 5, 2024 · Cisplatin causes neuropathy, cardiotoxicity, ototoxicity, hepatotoxicity, and nephrotoxicity [ 4–7 ]. Acute kidney injury (AKI) represents a noticeable adverse effect of cisplatin therapy as cisplatin accumulates in the kidney and causes a decline in vascular, glomerular, and tubular functions [ 4–7 ]. WebThe primary objective was to determine the clinical benefit of mannitol combined with hydration in terms of preventing cisplatin-induced acute kidney injury. The secondary end point was incidence of estimated glomerular filtration rate (eGFR) below 60 mL/min/1.73 m 2 at 7 days after receiving cisplatin between the two groups.

WebCisplatin is an antitumor drug used in the treatment of a wide variety of malignancies. However, its primary dose-limiting side effect is kidney injury, which is a major clinical concern. To help understand mechanisms involved in the development of kidney injury, cisplatin rodent model has been developed. Given the complex pathogenesis of kidney … WebDec 21, 2024 · myo -inositol; cisplatin; acute kidney injury; ferroptosis 1. Introduction Acute kidney injury (AKI) is an ominous clinical–pathologic state associated with the abrupt loss of renal functions and consequential complications. It is estimated that more than 20–50% of hospitalized patients are affected by various episodes of AKI [ 1 ].

WebSurgery-induced renal ischemia and reperfusion (I/R) injury and nephrotoxic drugs like cisplatin can cause acute kidney injury (AKI), for which there is no effective therapy. Lipid accumulation is evident following AKI in renal tubules although the mechanisms and pathological effects are unclear. Here, we report that Ehmt2-encoded histone ...

WebMar 29, 2024 · Administration of the chemotherapeutic agent cisplatin leads to acute kidney injury (AKI). Cisplatin-induced AKI (CIAKI) has a complex pathophysiological map, which has been linked to cellular … north lanarkshire nhs jobsWebSep 15, 2024 · Cisplatin is the prototype platinum coordination complex classified as an alkylating agent and used intravenously in the treatment of several forms of cancer. Cisplatin has been associated with a low rate of serum enzyme elevations and with rare cases of clinically apparent, acute liver injury. north lanarkshire online planningWebOct 1, 2024 · Cisplatin is a potent chemotherapeutic used for the treatment of many types of cancer. However, its dose-limiting side effect is nephrotoxicity leading to acute kidney injury (AKI). Patients who develop AKI have an increased risk of mortality and are more likely to develop chronic kidney disease (CKD). how to say neoadjuvantWebMay 18, 2024 · Vascular injuries caused by cisplatin may be due to an atypical hemolytic uremic syndrome. 58 Renal vascular pathology shows concentric subintimal thickening of small arteries and arterioles, with loose mucoid-appearing material and fibrin thrombi in afferent arterioles and glomerular capillaries. 58 From the age of 18 years to 80 years, … how to say neithWebOct 14, 2024 · Cisplatin effectiveness is reduced by its dose-limiting nephrotoxicity. Approximately 30% of patients administered cisplatin develop AKI.2There are no … how to say neitherWebThe prevalence of renal diseases including acute kidney injury (AKI) and chronic kidney disease (CKD) is increasing worldwide. However, the pathogenesis of most renal … how to say nepal in nepaliWebSep 2, 2024 · MLT alleviates cellular apoptosis after kidney injury caused by cisplatin, inhibiting the NF-κB–mediated inflammatory response and RIPK1/RIPK3 complex–mediated necroptosis (Kim et al., 2024). Meanwhile, MLT increases the expression of an anti-aging protein, Koltho, and prevents cellular apoptosis, resulting in maintaining the renal ... how to say nelson in maori